One step in understanding Canada’s iconic wood bison

There are plains bison and wood bison. Can you tell the difference?

Delta Genomics is developing a test that will tell whether bison are wood, plains or hybrid. The difference is important to conservation and production efforts.

Wood bison are part of Canada’s iconic charismatic megafauna, along with polar bears, caribou, moose and others. With only about 10,000 of them remaining (based on visual inspection of wild herds), the Committee on the Status of Endangered Wildlife in Canada has listed the species as having Special Concern. Plains bison, on the other hand, are quite plentiful. If you can’t tell the difference in these images, you’re not alone. So how do we know which to preserve?

“The CanSeq150 project is a science gift to Canada for our country’s 150th birthday last year,” says Delta Genomics CEO, Michelle Miller. “Basically, Canada’s Genomics Enterprise is sequencing 150 new genomes of animal or plant species that have significant scientific, cultural, societal or economic impact to Canada.”

CanSeq150’s goal is for the new genomes to serve as a foundation for biological research projects throughout the country. This initiative brought the beaver genome to Canada’s 150th birthday party, and has since sequenced the Canadian predator-prey duo, the snowshoe hare and lynx in 2017. The project still has an active call out for suggested species.

“We wanted to get the wood bison sequences for a few reasons,” says Michelle. “As part of an on-going project between Delta and the Canadian Bison Association, we are working to better understand the genetics of bison.”

Back in the 1920s, 6,000 plains bison were introduced into Wood Buffalo National Park in Northern Alberta, home to some of the last free-roaming wood bison herds. Yes, the bison interbred. No, there’s no good test to determine if an animal is wood, plains or hybrid. There’s even some debate as to whether they are genetically different. This is one of the questions Delta Genomics is hoping to answer. And for that, it needs lots of bison to sequence. The CanSeq150 project arrived at the perfect time.

The Canadian Bison Association has a two-pronged, synergistic mandate: conservation and production. The project with Delta involves developing the first genomics tools for the industry, which is something it doesn’t have access to yet. Genomics will benefit bison producers and conservationists by improving our ability to differentiate between wood and plains bison. There are three issues to address/answer:

  1. SNP parentage. The only parentage test using SNPs is US-based, which means mailing in samples to the States and paying in US dollars. Many producers don’t bother.
  2. Genetic difference. Is it possible to differentiate the percentage of wood and plains bison in an individual animal?
  3. How much cattle DNA is in an individual animal. Most bison have very little but current measurement methods aren’t very accurate.

“So we’d know how many pure wood bison there really are, from the conservation point of view,” says Michelle. “And on the production side, the knowledge will help producers in the same way that beef breeders maintain parental lines of Angus, Simmental, etc. Bison breeders are the same way. So producers need to know that, as well.”

But back to our original question. At Gentec, we’re not the type to leave you dangling. Here are the answers you’re looking for.

Genomics tools for commercial cattle producers: So what?

For the commercial cattle producer, crossbreeding is one of the least expensive ways to increase productivity, largely due to the resulting increase in hybrid vigour (scientifically known as heterosis / heterozygosity). In spite of this knowledge, the past 30 years have seen a continual erosion in heterosis in the cow herd as colour and “uniformity” became one of main considerations of cattle buyers. Crossbreeding, in contrast combines superior genetics from different breeds while eliminating any inbreeding depression. The Beef Cattle Research Council article “Have You Rotated Your Breeds Lately?” provides an excellent overview of why inbreeding depression occurs and some ways in which crossbreeding pays off so well for producers.

New tools are being developed that allow producers to use DNA to quantify heterosis (via breed composition) with an accuracy of 96%. This is superior to the degree of accuracy achieved with even the most accurate pedigree records due to the phenomenon of genetic “re-shuffling” that occurs on each chromosome in every generation. For example, an accurate pedigree calculation for a 100% Simmental bull crossed with a 50% Angus / 50% Hereford cow records a calf that is 50% Simmental x 25% Angus x 25% Hereford. In fact, the true genetics of the animal as a result of this “re-shuffling” might be 50% Simmental x 15% Angus x 35% Hereford. As an aside, the genomics method of breed composition automatically captures the neighbour’s bull who thinks the “grass” is greener on the other side of the fence.

But back to hybrid vigour… It is important to calculate heterosis accurately because the benefits are proportional (the greater the heterosis, the greater the benefits), the most economically important of which impact fitness, longevity, and reproductive productivity, the magnitude of which are as follows:

Every 10% increase in Vigour increases:

Pregnancy Rate                                 +2%                       2 more pregnancies per 100 cows*

Weaning Rate                                    +3%                       3 more weaned calves per 100 cows

Lifetime Productivity                      +79lbs                   79 additional pounds of saleable

calf over 5 calvings

Days in the Herd                               +51 days

So what does this mean for the commercial producer? Two things. One: knowing the heterosis present in heifers being considered as replacements helps you select for those animals that have the greatest probability of staying in the herd the longest and producing the most pounds of beef. At an estimated cost of $2,000 to develop a replacement heifer, the longer they last, the better your bottom line!

Second: knowing the genomics breed composition of your herd allows for the selection of those bulls / breeds that will allow you to continue to optimize your mating, selection, and culling decisions, the benefit of which have been estimated at over $200 as the return on the investment of a $45 genomic test. It’s all money in the bank.

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* As an example, an increase in average Vigour in a 100-cow herd from 50% to 70% would be expected to result in an additional 4 pregnancies and 6 weaned calves per year; 158 additional pounds of saleable calf / cow over 5 calvings; and an increase in the average number of days a cow stays in the herd of 101 days.

Demonstration Days are here again

2017 was a year of exciting firsts for Gentec and Delta Genomics.

In February, we launched the first genomics application for the commercial cow-calf sector discovered and commercialized within Alberta. The collaboration between the Grey Wooded Forage Association (GWFA) and Gentec as part of the Cow-Forage Gentec Tour demonstration event was our first involvement with a forage association, making the GWFA the first to deliver this information to its members. Last August’s event was one of our most highly rated demonstration events, with particular positive comments on the forage component for cow-calf producers and on the impact of Alberta Agriculture and Forestry (and Gentec collaborator) John Basarab’s presentation on genomics tools for commercial cow-calf producers.

Building on this success, Gentec and the Foothills Forage and Grazing Association (FFGA) in Southern Alberta are hosting two Forage to Beef Field-Demonstration Days in 2018: July 10 at the Waldron Ranch Grazing Cooperative (near Longview, AB), and July 11 co-located between Difficulty Ranch and at Whiskey Ridge Cattle Company (both near Didsbury, AB).

As in 2017, the overarching theme is sustainable beef production and the interaction of cows, forages and genomics in the optimal development and management of the cow-herd.

At the Waldron Ranch Grazing Cooperative on July 10, Mike Roberts, Ranch Manager, will compare plots that have never been grazed, continually grazed, and intermittently grazed. Here, presenters will discuss forage species, performance indicators, the production and environmental benefits (with yearling cattle on-site), the impacts of managing hybrid vigour within the cow herd as well as progress in developing genomic indexes for the commercial producer. There will also be a demonstration of how drones can be used in ranch management.

The second event, hosted jointly by Morrie and Debbie Goetjen (Whiskey Ridge Cattle Co.) and Sean and Holly LaBrie (Difficulty Ranch) will reflect the ecological and production techniques based on their local environmental conditions. They will showcase forage topics such as the cell, swath and bale-grazing techniques they use on-ranch, display their cow herd and discuss their beef production philosophy. The hybrid vigour and drone demonstrations from the previous day will be presented.

Both days will also see two prominent UofA Gentec collaborators presenting on the practical progress being made in forage production. Edward Bork, Director of UofA’s Rangeland Research Institute and Mattheis Chair in Rangeland Ecology and Management will use the forage plots on-hand to discuss the importance and methods of maintaining the long-term economic and environmental sustainability of rangelands at the producer level.
https://rri.ualberta.ca

Barry Irving has been coaxed out of a retirement lasting approximately 21 days) will talk about how management and research on both the forage and beef side has impacted production practices over the course of his career. Barry is the former manager of UofA’s Agricultural Research Stations that includes the Mattheis and Roy Berg Kinsella Research Ranches. Each station is home to distinct forage environments and active cattle herds.

More information and registration information available at https://livestockgentec.ualberta.ca and https://www.foothillsforage.com.

Local Boy Does Good…

This month’s featured video pays tribute to Gentec personality Dr. John Crowley as he advances another level in his rapidly evolving career. Some of our readers will know that as of July 1, John will be joining AbacusBio in its head office in Dunedin, New Zealand, for three months before settling into its international office in Edinburgh, Scotland.

John came to Gentec in 2011 from the Irish Cattle Breeding Federation, where he had been working as part of the genetic evaluation team.

Coming from a dairy and beef background and going on to be classically trained PhD in Quantitative Genetics, John was able to focus on the fact that the goal was always to help the science help the producer manage their operation and achieve production efficiencies. While always working as part of the Gentec / University of Alberta academic team, this drew John back to work with industry, initially as an Industry R&D Associate with Beefbooster from 2012 to 2014 (supported by Alberta Innovates), and in a similar position with the Canadian Beef Breeds Council immediately after that.

The video, filmed at Gentec’s 2018 One Genome One Health conference, provides an update on the Genome Alberta and Alberta Agriculture and Forestry project on “Development and deployment of MBVs/gEPDs for feed efficiency and carcass traits that perform in commercial beef cattle.” It shows John doing what he says he enjoys most about his roles in “helping to bridge the gaps between the academic role in discovery and innovation with that of facilitating the uptake and application of these new technologies by producers and industry … the interface of progress.”

In this presentation, John talks about the efforts to bring to the producer genomics tools and selection indexes that focus on traits of economic importance: feed efficiency and carcass traits such as carcass weight, marbling grade and lean yield.

One area where Gentec does “particularly well” (John’s words!) is in partnering with user groups who can benefit from the technology being developed. Here, that means working with Troy Drake of Cow Calf Health Management Solutions and 13 Alberta-based producers to provide genetic evaluations for commercial producers, increase the genetic merit of the cow herd by increasing the accuracy of genomics prediction tools and by delivering genomics breed composition to producers. This latter ability is demonstrating particular value as it allows commercial (crossbred) producers to optimize the value of hybrid vigour within their herd while taking advantage of breed complementarity (the fact that the different breeds have different strengths).

Valuable advances to be sure—but the science does not stop here … The next frontier involves gEPDs and selection indexes for maternal traits.

We wish John success in the next step in his career with one of Gentec’s partner organizations.